東京慈恵会医科大学 解剖学講座 岡部研究室
Model organisms
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Tsukiji N, Inoue O, Morimoto M, Tatsumi N, Nagatomo H, Ueta K, Shirai T, Sasaki T, Otake S, Tamura S, Tachibana T, Okabe M, Hirashima M, Ozaki Y, Suzuki-Inoue K.
Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction.
Blood. 2018 in press

Hirasaki Y, Tomita T, Yanagisawa M, Ueda K, Sato K, Okabe M.
Heart Anatomy of Rhincodon typus: Three-dimensional X-ray Computed Tomography of Plastinated Specimens.
Anat Rec. 2018 in press


Hashimoto H, Kawabe T, Fukuda T, Kusakabe M.
A Novel Ataxic Mutant Mouse Line Having Sensory Neuropathy Shows Heavy Iron Deposition in Kidney.
Neurodegener Dis. 2017 May 11;17(4-5):181-198.

Noda M, Miyake T, Okabe M.
Development of cranial muscles in the actinopterygian fish Senegal bichir, Polypterus senegalus Cuvier, 1829.
J Morphol. 2017 Apr;278(4):450-463.


Uchiyama T, Tatsumi N, Kamejima S, Waku T, Ohkido I, Yokoyama K, Yokoo T, Okabe M.
Hypermethylation of the CaSR and VDR genes in the parathyroid glands in chronic kidney disease rats with high phosphate diet.
Hum Cell. 2016 Oct;29(4):155-61.

Tatsumi N, Kobayashi R, Yano T, Noda M, Fujimura K, Okada N, Okabe M
Molecular developmental mechanism in polypterid fish provides insight into the origin of vertebrate lungs.
Sci Rep. 2016 Jul 28;6:30580.

Shigetani Y, Wakamatsu Y, Tachibana T, Okabe M
Conversion of neural plate explants to pre-placodal ectoderm-like tissue in vitro.
Biochem Biophys Res Commun. 2016 Sep 2;477(4):807-13.

Miyake T, Kumamoto M, Iwata M, Sato R, Okabe M, Koie H, Kumai N, Fujii K, Matsuzaki K, Nakamura C, Yamauchi S, Yoshida K, Yoshimura K, Komoda A, Uyeno T, Abe Y.
The pectoral fin muscles of the coelacanth Latimeria chalumnae; Functional and evolutionary implications for the fin-to-limb transition and subsequent evolution of tetrapods.
Anat Rec. 2016 Sep;299(9):1203-23.

Nagasawa T, Kawaguchi M, Yano T, Sano K, Okabe M, Yasumasu S.
Evolutionary changes in the developmental origin of hatching gland cells in basal ray-finned fishes.
Zoolog Sci. 2016 Jun;33(3):272-81.

Moriyama Y, Ito F, Takeda H, Yano T, Okabe M, Kuraku S, Keeley FW, Koshiba-Takeuchi K.
Evolution of the fish heart by sub/neofunctionalization of an elastin gene.
Nat Commun. 2016 Jan 19;7:10397.

Takeuchi-Igarashi H, Kubota S, Tachibana T, Murakashi E, Takigawa M, Okabe M, Numabe Y.
Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure.
Odontology. 2016 Jan;104(1):35-43.


Saijo H, Tatsumi N, Arihiro S, Kato T, Okabe M, Tajiri H, Hashimoto H.
Microangiopathy triggers, and inducible nitric oxide synthase exacerbates dextran sulfate sodium-induced colitis.
Lab Invest. 2015 Jul;95(7):728-48.

Hayashi S, Kobayashi T, Yano T, Kamiyama N, Egawa S, Seki R, Takizawa K, Okabe M, Yokoyama H, Tamura K.
Evidence for an amphibian sixth digit.
Zoological Lett.2015 Jun 15;1:17.

Izuhara L, Tatsumi N, Miyagawa S, Iwai S, Watanabe M, Yamanaka S, Katsuoka Y, Nagashima H, Okano HJ, Yokoo T.
Generation of a felinized swine endothelial cell line by expression of feline decay-accelerating factor.
PLoS One. 2015 Feb 11;10(2):e0117682.


Komoike N, Kato T, Saijo H, Arihiro S, Ito M, Hashimoto H, Okabe M, Koido S, Homma S, Tajiri H.
Photodynamic diagnosis by oral administration of 5-Aminolevulinic acid for colitis-associated dysplasia in mice model.
In Vivo. 2013 Nov-Dec;27(6):747-53.

Nikaido M, Noguchi H, Nishihara H, Toyoda A, Suzuki Y, Kajitani R, Suzuki H, Okuno M, Aibara M, Ngatunga BP, Mzighani SI, Kalombo HW, Masengi KW, Tuda J, Nogami S, Maeda R, Iwata M, Abe Y, Fujimura K, Okabe M, Amano T, Maeno A, Shiroishi T, Itoh T, Sugano S, Kohara Y, Fujiyama A, Okada N.
Coelacanth genomes reveal signatures for evolutionary transition from water to land.
Genome Res. 2013 Oct;23(10):1740-8.

Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, Miki Y, Yoshida K.
DYDYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.
Cancer Lett. 2013 Oct 10;339(2):214-25.

Dobashi A, Imazu H, Tatsumi N, Okabe M, Ang TL, Tajiri H.
Quantitative analysis of VEGF-C mRNA of extrahepatic cholangiocarcinoma with real-time PCR using samples obtained during endoscopic retrograde cholangiopancreatography.
Scand J Gastroenterol. 2013 Jul;48(7):848-55.

Katsu K, Tatsumi N, Niki D, Yamamura K, Yokouchi Y.
Multi-modal effects of BMP signaling on Nodal expression in the lateral plate mesoderm during left-right axis formation in the chick embryo.
Dev Biol. 2013 Feb 1;374(1):71-84.


Udagawa T, Tatsumi N, Tachibana T, Negishi Y, Saijo H, Kobayashi T, Yaguchi Y, Kojima H, Moriyama H, Okabe M.
Inwardly rectifying potassium channel Kir4.1 is localized at the calyx endings of vestibular afferents.
Neuroscience. 2012 Jul 26;215:209-16.

Moriyama Y, Kawanishi T, Nakamura R, Tsukahara T, Sumiyama K, Suster ML, Kawakami K, Toyoda A, Fujiyama A, Yasuoka Y, Nagao Y, Sawatari E, Shimizu A, Wakamatsu Y, Hibi M, Taira M, Okabe M, Naruse K, Hashimoto H, Shimada A, Takeda H.
The medaka enhancer mutant for zic1/zic4 provides molecular insights into teleost caudal fin evolution.
Curr Biol. 2012 Apr 10;22(7):601-7.

Ishkitiev N, Yaegaki K, Imai T, Tanaka T, Nakahara T, Ishikawa H, Mitiev V, Haapasalo M.
High-purity hepatic lineage differentiated from dental pulp stem cells in serum-free medium.
J Endod. 2012 Apr;38(4):475-80.

Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y.
BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo.
Dev Biol. 2012 Mar 1;363(1):15-26.

Shimada K, Tachibana T, Fujimoto K, Sasaki T, Okabe M.
Temporal and spatial cellular distribution of neural crest derivatives and alpha cells during islet development.
Acta Histochem Cytochem.2012 Feb 29;45(1):65-75.

Richardson J, Shono T, Okabe M, Graham A.
The presence of an embryonic opercular flap in amniotes.
Proc Biol Sci. 2012 Jan 22;279(1727):224-9.


Fujimura K, Conte MA, Kocher TD.
Circular DNA intermediate in the duplication of Nile tilapia vasa genes.
PLoS One. 2011;6(12):e29477.

Takechi M, Takeuchi M, Ota KG, Nishimura O, Mochii M, Itomi K, Adachi N, Takahashi M, Fujimoto S, Tarui H, Okabe M, Aizawa S, Kuratani S.
An overview of transcriptome profiles identified in hagfish, shark, and bichir: Current issues arising from some nonmodel vertebrate taxa
J Exp Zool B Mol Dev Evol. 2011 Nov 15;316(7):526-46.

Fujimura K, Kocher TD.
Tol2-mediated transgenesis in tilapia (Oreochromis niloticus).
Aquaculture. 2011 Oct 1;319(3-4):342-346.

Nakahara T
Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering.
Odontology. 2011 Jul;99(2):105-11.

Shono T, Kurokawa D, Miyake T, Okabe M.
Acquisition of glial cells missing 2 enhancers contributes to a diversity of ionocytes in zebrafish.
PLoS ONE. 2011;6(8):e23746.

Nemoto M, Hiki Y, Shimada K, Nakai N, Fujimoto K, Inoue S, Sakurada N, Kaneko H, Sugita M, Okabe M, Sasaki T.
Novel Hormonal Delivery Method Using the Ink-Jet Technology: Application to Pulmonary Insulin Therapies.
Diabetes Technol Ther. 2011 May;13(5):509-17.


Murata Y, Tamura M, Aita Y, Fujimura K, Murakami Y, Okabe M, Okada N, Tanaka M.
Allometric growth of the trunk leads to the rostral shift of the pelvic fin in teleost fishes.
Dev Biol. 2010 Nov 1;347(1):236-45.

Hirata TM, Ishkitiev N, Yaegaki K, Calenic B, Ishikawa H, Nakahara T, Mitev V, Tanaka T, Haapasalo M.
Expression of multiple stem cell markers in dental pulp cells cultured in serum-free media.
J Endod. 2010 Jul;36(7):1139-44.

Suzuki M, Tominaga N, Ide Y, Ohyama A, Nakahara T, Ishikawa H, Tanaka A, Mataga I.
Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs.
Hum Cell. 2010 May;23(2):65-73.

Kuwahara H, Horie T, Ishikawa S, Tsuda C, Kawakami S, Noda Y, Kaneko T, Tahara S, Tachibana T , Okabe M , Melki J, Takano R, Toda T, Morikawa D, Nojiri H, Kurosawa H, Shirasawa T, Shimizu T. 
Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy. 
Free Radic Biol Med. 2010 May 1;48(9):1252-62.

Ishkitiev N, Yaegaki K, Calenic B, Nakahara T, Ishikawa H, Mitiev V, Haapasalo M.
Deciduous and permanent dental pulp mesenchymal cells acquire hepatic morphologic and functional features in vitro.
J Endod. 2010 Mar;36(3):469-74.

Amemiya CT, Powers TP, Prohaska SJ, Grimwood J, Schmutz J, Dickson M, Miyake T, Schoenborn MA, Myers RM, Ruddle FH, Stadler PF.
Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome.
Proc. Nat. Acad. Sci. USA. 2010 Feb 5;107:3622-7.

Nakahara T, Tamaki Y, Tominaga N, Ide Y, Nasu M, Ohyama A, Sato S, Ishiwata I, Ishikawa H.
Novel amelanotic and melanotic cell lines NM78-AM and NM78-MM derived from a human oral malignant melanoma.
Hum Cell. 2010 Feb 1;23(1):15-25.


Hiramatsu M, Iwashita M, Inagaki T, Matsudaira H, Hirano J, Odaka M, Nakanishi K, Okabe M, Morikawa T.
Anomalous systemic arterial supply to two separate segments of the lung: An anatomical consideration. 
Ann Thorac Surg. 2009 Oct;88(4):1358-60.

Hama T, Yuza Y, Saito Y, O-uchi J, Kondo S, Okabe M, Yamada H, Kato T, Moriyama H, Kurihara S, Urashima M.
Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma.
Oncologist. 2009 Sep ;14(9):900-8.

Ide Y, Nakahara T, Nasu M, Tominaga N, Ohyama A, Tachibana T, Yasuda M.
Establishment and characterization of the NEYS cell line derived from carcinosarcoma of human ovary with special reference to the susceptibility test of anticancer drugs.
Hum Cell
. 2009 Aug;22(3):72-80.

Takeuchi M, Takahashi M, Kuratani S, Okabe M, Aizawa, S.
Germ layer patterning in bichir and lamprey; An insight into its evolution in vertebrates. 
Dev Biol. 2009 Aug 1;332(1):90-102.

Fukui A, Yokoo T, Matsumoto K, Kawamura T, Hosoya T, Okabe M.
Integration of human mesenchymal stem cells into the Wolffian duct in chicken embryos.
Biochem Biophys Res Commun. 2009 Jul 31;385(3):330-5.

Takeuchi M, Okabe M, Aizawa S.
The Genus Polypterus (Bichirs): A Fish Group Diverged at the Stem of Ray-Finned Fishes (Actinopterygii). 
CSH Protocols
. 2009; doi:10.1101/pdb.emo117

Takeuchi M, Okabe M, Aizawa S.
Whole-Mount In Situ Hybridization of Bichir (Polypterus) Embryos.
 CSH Protocols. 2009; doi:10.1101/pdb.prot5158

Takeuchi M, Okabe M, Aizawa S.
Microinjection of Bichir (Polypterus) Embryos. 
CSH Protocols
. 2009; doi:10.1101/pdb.prot5157

Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Shiraishi Y, Futatsugi N, Mizutani-Koseki Y, Kuroiwa A, Shirouzu M, Yokoyama S, Taiji M, Iseki S, Ornitz DM, Koseki H.
FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.
Nat Genet
. 2009 Mar;41(3):289-98.

Kurusu M, Maruyama Y, Adachi Y, Okabe M, Suzuki E, Furukubo-Tokunaga K.
A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain.
Dev Biol
. 2009 Feb 1;326(1):224-36.

Iwaizumi M, Shinmura K, Mori H, Yamada H, Suzuki M, Kitayama Y, Igarashi H, Nakamura T, Suzuki H, Watanabe Y, Hishida A, Ikuma M, Sugimura H.
Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer.
. 2009 Feb;58(2):249-60.

Smith MM, Okabe M, Joss J.
Spatial and temporal pattern for the dentition in the Australian lungfish revealed with sonic hedgehog expression profile.
Proc Biol Sci
. 2009 Feb 22; 276:623-31.

Kidokoro H, Okabe M, Tamura K.
Time-lapse analysis reveals local asymmetrical changes in C-looping heart tube.
Dev Dyn. 2008 Dec;237(12):3545-56.

Yamashita S, Takahashi N, Hashimoto H, Tachibana T, Nakahara T, Ohyama A, Yanaga K.
Establishment and characterization of a cell line (IGSK-3) secreting human chorionic gonadotropin, adrenocorticotropic hormone and parathyroid hormone-related protein derived from primary poorly differentiated adenocarcinoma of the stomach.
Hum Cell
. 2008 Aug;21(3):88-94.

Shigetani Y, Howard S, Guidato S, Furushima K, Abe T, Itasaki N.
Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development.
Dev Biol
. 2008 Jul 15;319(2):346-58.

Matsumoto K, Miki R, Nakayama M, Tatsumi N, Yokouchi Y.
Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium.
Dev Biol. 2008 Jul 15;319(2):234-47.

Tanaka K, Hashimoto H, Tachibana T, Ishikawa H, Ohki T.
Apoptosis in the small intestine of neonatal rat using blue light-emitting diode devices and conventional halogen-quartz devices in phototherapy.
Pediatr Surg Int. 2008 Jul;24 (7):837-42.

Yokoo T, Fukui A, Matsumoto K, Ohashi T, Sado Y, Suzuki H, Kawamura T, Okabe M, Hosoya T.
Generation of a transplantable erythropoietin-producer derived from human mesenchymal stem cells.
. 2008 Jun 15;85(11):1654-58.

Yanai M, Tatsumi N, Hasunuma N, Katsu K, Endo F, Yokouchi Y.
FGF signaling segregates biliary cell-lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro.
Dev Dyn. 2008 May;237(5):1268-83.

Miki R, Tatsumi N, Matsumoto K, Yokouchi Y.
New primary culture systems to study the differentiation and proliferation of mouse fetal hepatoblasts.
Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G529-39.

Ito T, Ohi S, Tachibana T,Takahara M, Hirabayashi T, Ishikawa H, Kusakabe M, Hashimoto H.
Development of the mucosal vascular system in the distal colon of the fetal mouse.
Anat Rec (Hoboken). 2008 Jan;291(1):65-73.

Hashimoto H, Kusakabe M, Ishikawa H.
A novel method for three-dimensional observation of the vascular networks in the whole mouse brain.
Microsc Res Tech. 2008 Jan;71(1):51-9.

Yokoo T, Fukui A, Matsumoto K, Okabe M.
Stem cells and kidney organogenesis.
Front Biosci. 2008 Jan 1;13:2814-32.
Matsuno M, Kose H, Okabe M, Hiromi Y.
TFIIH controls developmentally-regulated cell cycle progression as a holocomplex.
Genes Cells. 2007 Nov;12(11):1289-300.

Jin S .
Novel method for the establishment of cardiomyocytes derived from rat embryonic stem cells in vitro.
Hum Cell. 2007 Nov;20(4):111-8.

Shimizu H, Okabe M.
Evolutionary origin of autonomic regulation of physiological activities in vertebrate phyla.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Oct;193(10):1013-9.

Shigetani Y
, Itasaki N.
Expression of Wise in chick embryos.
Dev Dyn. 2007 Aug;236(8):2277-84.

Ninomiya K, Ohi S, Tabei I, Jin S, Tachibana T, Yamashita S, Yanaga K, Hashimoto H.
Establishment and characterization of a cell line (BTIC) including HER-2-positive cells derived from pleural effusion of recurrent breast invasive ductal carcinoma, scirrhous type.
Hum Cell. 2007 Aug;20(3):85-90.

Ohi S, Takahashi N, Hashimoto H, Tachibana T, Hirabayashi T, Sugiyama K, Yanaga K, Ishikawa H.
Establishment and characterization of an IGSK-2 cell line derived from ascitic fluid of recurrent hCG and somatostatin secreted adenocarcinoma of the stomach.
Hum Cell. 2007 May;20(2):52-61.

Ohi S.
Characterization, anticancer drug susceptibility and atRA-induced growth inhibition of a novel cell line (HUMEMS) established from pleural effusion of alveolar rhabdomyosarcoma of breast tissue.
Hum Cell. 2007 May;20(2):39-51.

Ohi S, Takahashi N, Ninomiya K, Nakajima M, Hashimoto H, Tachibana T, Yanaga K, Ishikawa H.
Establishment and characterization of a cisplatin-resistant cell line (IGSK-1) from a poorly differentiated gastric adenocarcinoma.
Hum Cell
. 2007 Feb;20(1):15-22.
2006 © Masataka Okabe